Ĭhronic pain is defined as any persistent pain that lasts for more than three months, a debilitating condition with increased prevalence in older adults. Shorter LTL is also associated with an increased risk of morbidity and mortality. The elevated inflammatory state serves as a contributing factor in the pathogenesis and progression of many age-related disease conditions, including the development of chronic pain. Not only does inflammation within the cellular environment contribute to telomere shortening, but the accumulation of senescent cells and the senescence-associated secretion of pro-inflammatory cytokines also contribute to the low-grade chronic inflammatory state of aging adults. Telomere shortening has been linked to cellular aging processes, such as genomic instability and cellular senescence. Leukocyte telomere length (LTL) is widely studied as a biomarker of cellular aging. Findings highlight the complex relationships between anti-inflammatory micronutrients, inflammation, cellular aging, and chronic pain. In individuals with chronic pain, based on clinical categories, significant associations between vitamin D, omega 6:3 ratio, and CRP were observed. Although an association between the continuous micronutrients and LTL was not observed, a positive association between omega 6:3 ratio and CRP was detected. Data were analyzed with general linear regression. LTL was measured in genomic DNA isolated from blood leukocytes, and micronutrients and CRP were measured in serum samples. Chronic pain was assessed as pain experienced for at least three months. ![]() Demographic and health information was collected. A cross-sectional analysis of 402 individuals (63% women, 79.5% with chronic pain) was completed. We investigate associations between vitamin D, omega 6:3 ratio, LTL, and C-reactive protein (CRP) in people living with/without chronic pain overall and stratified by chronic pain status. Little is known regarding the relationships between vitamin D, omega 6:3 ratio, LTL, inflammation, and chronic pain. ![]() Micronutrients, such as 25-hydroxyvitamin D (vitamin D) and omega 3, have anti-inflammatory properties. Elevated inflammatory cytokines and chronic pain are associated with shorter leukocyte telomere length (LTL), a measure of cellular aging.
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